COMPARISON OF SERUM -HEXOSAMINIDASE ISOENZYME B ACTIVITY WITH SERUM CARBOHYDRATE-DEFICIENT TRANSFERRIN AND OTHER MARKERS OF ALCOHOL ABUSE
نویسندگان
چکیده
منابع مشابه
Forensic aspects of postmortem serum carbohydrate-deficient transferrin analysis as a marker of alcohol abuse.
INTRODUCTION Carbohydrate-deficient transferrin (CDT) has been suggested as one of alcohol abuse indicators having produced good results in forensic medicine for years. OBJECTIVE The aim of the study was to identify correlation between present methodology of alcohol abuse diagnosis at autopsy (macroscopic and microscopic findings) and CDT examination using the method of isoelectrofocusing (IE...
متن کاملCarbohydrate-deficient transferrin: a marker of alcohol abuse.
Serum carbohydrate-deficient transferrin (CDT) measurement is valuable for the identification of chronic excess alcohol consumption. CDT is increased in serum in approximately 50% of those classed as heavy drinkers and 70-80% of those defined as alcoholics. With abstinence, the serum CDT concentration reverts towards normal within approximately 2 weeks. Specificity for alcohol abuse ranges from...
متن کاملInterference of transferrin isoform types with carbohydrate-deficient transferrin quantification in the identification of alcohol abuse.
BACKGROUND Isoforms of transferrin interfere with measurement of carbohydrate-deficient transferrin (CDT) as a marker of heavy alcohol consumption. We evaluated the rate of inaccurate CDT results by immunoassays. METHODS We studied 2360 consecutive sera (1614 individuals) submitted for CDT assay without clinical information as well as samples from 1 patient with a congenital disorder of glyco...
متن کاملA comparison of carbohydrate deficient transferrin with other markers of alcohol misuse in male soldiers under the age of thirty.
The paper describes a study of 58 consecutive male soldiers under 30 years old admitted to an alcohol treatment unit in London, and 51 age- and gender-matched controls to compare the efficacy of isoelectric focusing, a non-quantitative measure of carbohydrate deficient transferrin (CDT), with other markers of alcohol misuse. The Severity of Alcohol Dependence Questionnaire, the Michigan Alcohol...
متن کاملCarbohydrate-deficient transferrin in serum: a new marker of potentially harmful alcohol consumption reviewed.
During the last 16 years an increasing number of studies have indicated a new diagnostic marker of alcohol abuse, unrelated to any of the conventional markers of alcoholism. This marker, now called carbohydrate-deficient transferrin, consists mainly of one or two isoforms of transferrin that are deficient in their terminal trisaccharides. Such isoforms have so far been detected by methods based...
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ژورنال
عنوان ژورنال: Alcohol and Alcoholism
سال: 1997
ISSN: 0735-0414,1464-3502
DOI: 10.1093/oxfordjournals.alcalc.a008320